Marc W. Kirschner Ph.D.

    The Kirschner lab studies spatial organization and temporal control in several different biological contexts, including the cell cycle, the cytoskeleton, and embryonic development. They also study a number of important signaling pathways, notably the Wnt pathway and various post-translational modification systems.

Department Faculty

    Markus Basan, PhD

    Our lab seeks a more quantitative and predictive understanding of physiology on the cellular and organism scale. Guided by phenotypic patterns, we try to identify underlying principles governing the behavior of complex biological systems. Current questions include the role of metabolic strategies during growth and adaptation and how homeostasis of cell size, number and composition is achieved.

    Angela DePace Ph.D.

    The DePace lab studies the mechanism and evolution of gene regulation using the early development of 12 Drosophila species as a model system. Their goal is to understand how regulatory information is encoded in the genome, how it is deciphered as gene expression patterns in space and time, and how it changes during evolution.

    Galit Lahav Ph.D.

    The Lahav lab studies the temporal dynamics of biological signals by combining quantitative live imaging of single human cells with mathematical modeling. They primarily study the signaling pathway of the tumor suppressor p53, with the goal of understanding how the dynamic behavior of p53 is controlled, and how dynamics affects cell fate decisions.

    Eric S. Lander Ph.D.

    In creating the Broad Institute, Lander and colleagues have nucleated a community of researchers from the Cambridge-Boston area to tackle complex problems related to developing comprehensive tools for genomic medicine and applying them to the study of disease. This research effort requires cooperation across scientific disciplines from basic biology to chemistry, basic science to clinical science, and collaboration across institutions.

    Debora Marks, Ph.D.

    Evolution has deposited rich information in the genomes of all species over time, as a result of mostly hidden functional constraints. The Marks lab will provide mathematical and computational bridge that can exploit this information to address critical challenges in biomedical research such as the consequences of human genetic variation, mutation effect on disease likelihood, drug resistance and drug response.

    Sean G. Megason Ph.D.

    The Megason lab is interested in how the program contained in the genome is executed during development to turn an egg into an embryo. We use confocal/2-photon imaging of living, transgenic zebrafish embryos to watch biological circuits function in vivo and use these data in cell-based, quantitative modeling.

    Timothy J. Mitchison Ph.D.

    We work on fundamental questions of how cells are spatially organized applied problems in pharmacology and drug development. We ask how systems comprising microtubules, binding proteins and motors self-organize to promote cell division in frog eggs using microscopy and biochemistry. We work on the pharmacology of microtubule-targeting drugs, and to development new drug that combat cancer and inflammation by modulating innate immunity.

    Vamsi Mootha M.D.

    The Mootha lab aims to characterize the structure and dynamic properties of the biological networks underlying mitochondrial function, link variation in these parameters to genetic variation, and exploit the network properties of the organelle to design therapies for human disease.

    Jagesh V. Shah Ph.D.

    The Shah lab is interested in understanding how molecular events drive the behavior of cell-scale structures. They use molecular techniques and modern biophysical tools to develop quantitative models of endogenous and synthetic cellular networks.

    Pamela A. Silver Ph.D.

    The Silver Lab works at the interface between systems and synthetic biology to design and build biological systems in both mammalian and prokaryotic cells. We seek to both gain a further understanding of biological design principles and create biological solutions to problems of health and sustainability.  Some current projects include development of cells that record past events and actuate, cell-based computation and therapeutics, rebooting the gut microbiome and development of the bionic leaf.

    Peter Sorger Ph.D.

    The Sorger lab applies experimental and computational methods to the analysis of mechanical and regulatory processes controlling eukaryotic cell division. They seek to construct data-driven, systems-wide models of cellular function that contain detailed mechanistic information on the activities of individual proteins.

Visiting Faculty

    Roy Kishony Ph.D.

    The Kishony lab is interested in understanding the system-level architecture of genetic networks and the interplay between their design and the evolutionary process. They combine theoretical and experimental approaches to study epistasis networks – networks that describe how perturbations (mutations or drugs) in a given biological system combine to aggravate or alleviate each other’s effect on a phenotype.

Lecturers & Instructors

    Gavin MacBeath Ph.D.

    The MacBeath lab is interested in  identifying, characterizing, and perturbing large collections of proteins or protein domains as a first step in understanding how the cell exploits molecular recognition to regulate complex processes such as protein trafficking, intercellular communication, growth factor signaling, and apoptosis.

    Laura Maliszewski Ph.D.

    Laura Maliszewski, PhD joined HMS in September 2012 to manage the development of the Laboratory of Systems Pharmacology and the Harvard Program in Therapeutic Science. She served previously as an Officer in the Science and Innovation Network of the UK Foreign and Commonwealth Office, developing a broad portfolio of research collaborations in regenerative medicine, health economics and stratified medicine.

    Mario Niepel Ph.D.

    A key challenge in treating cancer is the wide range of effectiveness of current targeted therapeutics and the rapid development of resistance. I am trying to understand the mechanisms of drug responses and development of resistance using established breast cancer cell lines as a model system, since they mirror much of the behavior and heterogeneity of primary disease. I mainly study therapeutic drugs and ligands to receptor tyrosine kinases that modulate signaling through the ErbB family and the PI3K/AKT signaling pathways, which are particularly important in the development and treatment of breast and ovarian cancer. Ultimately, a detailed understanding of drug action will move us towards the development of a more personalized medicine, where tumors from each patient are analyzed on a molecular level so they can be treated with specifically tailored drugs or combinations that have been predicted to maximize efficacy and minimize the risk of resistance and toxicity.

    I focus most of my work on proteins, rather than genomic measures, since they are both the key effectors of cellular function and the targets of the drugs. In my research I combine a variety of protein profiling methods, detailed measurements of phenotypic responses, and biochemical investigation into drug action. I analyze the data by statistical and computational methods to identify both predictors of drug response and the causal determinants drug sensitivities.

    Caroline Shamu Ph.D.

    Dr. Shamu is the Director of the ICCB-Longwood Screening Facility. The ICCB-Longwood Investigator Initiated Screening Program assists academic researchers in carrying out high-throughput screens of chemical and RNAi libraries to identify new tools for biological research. In addition to her expertise in implementing new high throughput assay technologies, Dr.Shamu is active in the development of data standards and repositories for large-scale datasets from high-throughput assays.

Affiliated Faculty

    L. Mahadevan Ph.D.

    The Mahadevan group is interested in understanding the organization of matter in space and time, particularly at the scale observable by our unaided senses. We use a combination of techniques to pursue this, ranging from simple observations of phenomena to quantitative experiments and theory.

Department Fellows

    Mohammed AlQuraishi PhD.

    Dr. AlQuraishi's research interests lie at the intersection of systems and structural biology. He aims to obtain a systems-level understanding of biological processes through a molecular-level understanding of biological structures and their interactions. Towards that end he is developing computational methods for predicting the binding partners and quantitative binding affinities of biological molecules from their atomic structure.

    Martin Loose Ph.D.

    Dr. Loose's  research goal is to investigate the mechanisms of biochemical self-organization. He is particularly interested in how minimal protein systems are able to organize intracellular space and how these biochemical modules are conserved or change during evolution. For this he mainly uses biochemical approaches and microscopic techniques.