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Faculty

Department Chair

M. KirschnerMarc W. Kirschner, Ph.D.
Professor of Systems Biology

Marc W. Kirschner, Ph.D. is founding chair of the Department of Systems Biology. His lab studies, among many other things, the way a developing frog embryo orchestrates numerous signals to yield the final, complex organism.

E-mail:
Website: http://kirschner.med.harvard.edu/

 

Department Faculty

Lewis C. CantleyLewis C. Cantley, Ph.D.
Professor of Systems Biology

The major research objective of Lew’s laboratory is to understand the biochemical pathways that regulate normal mammalian cell growth and the defects that cause cell transformation.

E-mail:

 

A. DePaceAngela DePace, Ph.D.
Assistant Professor of Systems Biology

Our lab studies the mechanism and evolution of gene regulation. Using the early development of 12 recently sequenced Drosophila species as a model system, we hope to understand how regulatory information is encoded in the genome, how it is deciphered as gene expression patterns in space and time, and how it changes during evolution to contribute to organismal diversity.

Email:
Website: http://depace.med.harvard.edu

 

W. FontanaWalter Fontana, Ph.D.
Professor of Systems Biology

Walter's lab combines experimental and theoretical approaches to address fundamental problems in systems biology as they relate to aging (C.elegans), plasticity in molecular signaling, and the evolvability of phenotype.

Email:
Website:http://fontana.med.harvard.edu/

 

J. GunawardenaJeremy Gunawardena, Ph.D.
Director, Virtual Cell Program
Senior Lecturer in Systems Biology

Jeremy’s lab studies signal transduction through single-cell experiments and mathematical models and by developing the Virtual Cell, a computational facility for in-silico systems biology.

E-mail:
Web site : http://vcp.med.harvard.edu/

 

R. KishonyRoy Kishony , Ph.D.
Associate Professor of Systems Biology

Our lab is interested in understanding the system-level architecture of genetic networks and the interplay between their design and the evolutionary process. We are combining theoretical and experimental approaches to study epistasis networks - networks that describe how perturbations (mutations or drugs) in a given biological system are combined to aggravate or alleviate the phenotypic consequences of each other.

E-mail:
Web site : http://kishony.med.harvard.edu/


G. LahavGalit Lahav, Ph.D.
Assistant Professor of Systems Biology

Galit’s lab is studying the temporal dynamics of biological signals by combining quantitative live imaging of single human cells together with mathematical modeling. They focus on the signaling pathway of the tumor suppressor p53, and aim to understand how the dynamics behavior of p53 is controlled and how it affects cell fate decisions.

E-mail:
Web site: http://lahav.med.harvard.edu/

 

E. LanderEric S. Lander, Ph.D.
Professor of Systems Biology

Eric and colleagues are using the knowledge of the human genome to tackle a fundamental issue of medicine: to find the molecular mechanisms underlying the basis of human disease.

E-mail:
Web site: http://www.wi.mit.edu/far/far_lander_bio.html

 

S. MegasonSean G. Megason , Ph.D.
Assistant Professor of Systems Biology

Sean’s lab is interested in how the program contained in the genome is executed during development to turn an egg into an embryo. We use confocal/2-photon imaging of living, transgenic zebrafish embryos to watch biological circuits function in vivo and use these
data
in cell-based, quantitative modeling.

E-mail:
Website: http://megason.med.harvard.edu

 

T. MitchisonTimothy J. Mitchison, Ph.D. (Deputy Chair)
Hasib Sabbagh Professor of Systems Biology

Tim's lab is interested in the structure, dynamics, and function of the cytoskeleton. They use imaging-based assays in living cells and in vitro extracts, in conjunction with molecular biology and biochemical fractionation approaches.

Email:
Web site: http://mitchison.med.harvard.edu/

 

V. MoothaVamsi Mootha, M.D.
Assistant Professor of Systems Biology

Vamsi’s lab is broadly interested in characterizing the structure and dynamic properties of the biological networks underlying mitochondrial function, linking variation in these parameters to genetic variation, and exploiting the network properties of the organelle to design therapies for human disease.

Email:
Web site: http://mootha.med.harvard.edu/

 

J. PaulssonJohan Paulsson, Ph.D.
Assistant Professor of Systems Biology

 

 

Email:
Web Site: http://paulsson.med.harvard.edu/

 

V. MoothaJagesh V. Shah, Ph.D.
Assistant Professor of System Biology

Jagesh’s lab is broadly interested in scaling molecular events into cell behavior.  Using molecular techniques and modern biophysical tools they are piecing together quantitative models of endogenous and synthetic cellular networks.

Email:

 

P. SilverPamela A. Silver, Ph.D.
Professor of Systems Biology

Pam's group studies the design of biological systems, the organization of the genome in the nucleus, synthetic biology and bio-energy.

Email:
Web Site: http://silver.med.harvard.edu/
WIKI: http://openwetware.org/wiki/Silver_Lab

 

 

P. SorgerPeter Sorger Ph.D.
Professor of Systems Biology

Peter's lab applies experimental and computational methods to the analysis of mechanical and regulatory processes controlling eucaryotic cell division. They seek to construct data-driven, systems-wide models of cellular function that nonetheless contain detailed mechanistic information on the activities of individual proteins. Research focuses on the microtubule-based machines that segregate chromosomes during mitosis and on the signal transduction networks that regulate cell proliferation and death. Defects in these pathways are known to predispose cells to oncogenic transformation and we are actively developing a pharmacological approach in which disease and therapy are viewed through the prism of quantitative numerical models.

Email:

 

P. SorgerRalph Weissleder M.D., Ph.D.
Professor of Systems Biology and Radiology

Ralph Weissleder, Ph.D. is Director of the MGH Center for Systems Biology, one of MGH’s 5 Thematic Research Centers. His lab has been a driving force in the development of novel imaging tools and their application to understanding complex diseases. He has developed systematic ways to explore disease biology using library approaches and has been instrumental in translating several discoveries into new drugs.

Email:
Website: http://csb.mgh.harvard.edu

 

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