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Faculty |
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Department Chair
Marc W. Kirschner, Ph.D. is founding chair of the Department of Systems Biology. His lab studies, among many other things, the way a developing frog embryo orchestrates numerous signals to yield the final, complex organism. E-mail:
Department Faculty
The major research objective of Lew’s laboratory is to understand the biochemical pathways that regulate normal mammalian cell growth and the defects that cause cell transformation. E-mail:
Our lab studies the mechanism and evolution of gene regulation. Using the early development of 12 recently sequenced Drosophila species as a model system, we hope to understand how regulatory information is encoded in the genome, how it is deciphered as gene expression patterns in space and time, and how it changes during evolution to contribute to organismal diversity. Email:
Walter's lab combines experimental and theoretical approaches to address fundamental problems in systems biology as they relate to aging (C.elegans), plasticity in molecular signaling, and the evolvability of phenotype. Email:
Jeremy’s lab studies signal transduction through single-cell experiments and mathematical models and by developing the Virtual Cell, a computational facility for in-silico systems biology. E-mail:
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Galit’s lab is studying the temporal dynamics of biological signals by combining quantitative live imaging of single human cells together with mathematical modeling. They focus on the signaling pathway of the tumor suppressor p53, and aim to understand how the dynamics behavior of p53 is controlled and how it affects cell fate decisions. E-mail:
Eric and colleagues are using the knowledge of the human genome to tackle a fundamental issue of medicine: to find the molecular mechanisms underlying the basis of human disease. E-mail:
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Tim's lab is interested in the structure, dynamics, and function of the cytoskeleton. They use imaging-based assays in living cells and in vitro extracts, in conjunction with molecular biology and biochemical fractionation approaches. Email:
Vamsi’s lab is broadly interested in characterizing the structure and dynamic properties of the biological networks underlying mitochondrial function, linking variation in these parameters to genetic variation, and exploiting the network properties of the organelle to design therapies for human disease. Email:
The goal of the laboratory is to identify and understand the guiding principles behind these different phenomena. To this end we derive mathematical methods to interpret fluctuations, develop experimental methods to count molecules in single cells, and combine the two to study the simplest natural and engineered networks. Email:
Jagesh’s lab is broadly interested in scaling molecular events into cell behavior. Using molecular techniques and modern biophysical tools they are piecing together quantitative models of endogenous and synthetic cellular networks. Email:
Pam's group studies the design of biological systems, the organization of the genome in the nucleus, synthetic biology and bio-energy. Email:
Peter's lab applies experimental and computational methods to the analysis of mechanical and regulatory processes controlling eucaryotic cell division. They seek to construct data-driven, systems-wide models of cellular function that nonetheless contain detailed mechanistic information on the activities of individual proteins. Research focuses on the microtubule-based machines that segregate chromosomes during mitosis and on the signal transduction networks that regulate cell proliferation and death. Defects in these pathways are known to predispose cells to oncogenic transformation and we are actively developing a pharmacological approach in which disease and therapy are viewed through the prism of quantitative numerical models. Email:
Mike's lab is interested in how evolution shapes and constrains how organisms respond to their environment. They analyze cellular responses in several related yeast species using a combination of in vivo fluorescence, synthetic and genetic approaches, and numerical and analytical modeling. Email:
Ralph Weissleder, Ph.D. is Director of the MGH Center for Systems Biology, one of MGH’s 5 Thematic Research Centers. His lab has been a driving force in the development of novel imaging tools and their application to understanding complex diseases. He has developed systematic ways to explore disease biology using library approaches and has been instrumental in translating several discoveries into new drugs. Email:
Peng's group is generally interested in developing programmable molecular systems and technology inspired by biology. The lab currently focuses on engineering information-directed self-assembly of nucleic acid (DNA/RNA) structures and devices, and on exploiting such systems to do useful molecular work, e.g. probing and programming biological processes for imaging and therapeutic applications. Email:
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