Vadim Gladyshev Department of Medicines and Genetics Brigham & Women's Hospital, Boston
Title: Mechanisms of aging and longevity
Abstract: What is aging? When does it begin? Is it a normal, physiological process that predisposes to pathology/disease, or it is a pathology/disease itself? How can the aging process be delayed? Can it be reversed? How does Nature solve these questions, as there is a great diversity in aging patterns and lifespans across species, cell types, and model organisms? These are...
Katie Bentley Department of Immunology, Genetics and Pathology Uppsala University, Sweden
Title: Temporal adaptation of collective cell behaviour and vascular branching structures
Abstract: How long does it take cells to collectively make a decision? And how do local tissue conditions impact the speed of collective deliberations, and the subsequent morphogenesis they control? These are the questions I will focus on, considering specifically how endothelial cells decide when and where to extend...
Title: Models for the initiation of T cell activation
Abstract: This talk is concerned with mathematical models describing events during the first few minutes after the encounter of a naive mature T cell with its antigen. I will describe results obtained with Eduardo Sontag showing that some of these models exhibit behaviour which had not previously been noticed such as multiple steady states and damped oscillations. In addition I will discuss features of the response function which are predicted...
Elizabeth Tran Department of Biochemistry Purdue University
Title: Dynamic regulation of gene expression by long non-coding RNAs
Abstract: Long non-coding (lnc)RNAs, once thought to merely represent noise from imprecise transcription initiation, have now emerged as major regulatory entities of gene expression in all eukaryotes. Major efforts are now being put forth to identify the mechanism(s) of action for individual lncRNAs. Using the budding yeast S. cerevisiae as a model, we found that lncRNAs associated...
Vadim Gladyshev Department of Medicines and Genetics Brigham & Women's Hospital, Boston
Title: Mechanisms of aging and longevity
Abstract: What is aging? When does it begin? Is it a normal, physiological process that predisposes to pathology/disease, or it is a pathology/disease itself? How can the aging process be delayed? Can it be reversed? How does Nature solve these questions, as there is a great diversity in aging patterns and lifespans across species, cell types, and model organisms? These are...
Katie Bentley Department of Immunology, Genetics and Pathology Uppsala University, Sweden
Title: Temporal adaptation of collective cell behaviour and vascular branching structures
Abstract: How long does it take cells to collectively make a decision? And how do local tissue conditions impact the speed of collective deliberations, and the subsequent morphogenesis they control? These are the questions I will focus on, considering specifically how endothelial cells decide when and where to extend...
