Seminar: Mogens Høgh Jensen

Date: 

Tuesday, January 23, 2018, 1:00pm to 2:30pm

Location: 

WAB 563

Title: Couples Oscillations in Biology

Abstract: The control of proteins by a transcription factor with periodically varying concentration exhibits intriguing dynamical behavior. If the concentration of another element, for instance a ligand responsible for the activation of the transcription factor, is oscillating as well, the system of coupled oscillators can create regions of bistable oscillation states. We investigate how transitions between different entrained states caused by intrinsic noise affect the expression of downstream genes. We find that by changing the amplitude of the ligand, we can control the effect of the intrinsic noise and as a result regulate which types of genes should be in high and which should be in low production states. We further find that driving the system into a chaotic state, is an effective and noise independent way to modulate gene production and specifically up-regulate specific families of low-affinity genes. This means that complex dynamics can be used advantageously to regulate proteins on different timescales and create both homogeneous and heterogeneous populations.