Systems Biology Post Docs' final departmental talk before they move on.

Title: Fate coordination and collective migration: Statphys of multicellular dynamics

Jacques Loeb Centre for the History and Philosophy of the Life Sciences
Ben-Gurion University of the Negev, Israel

Title: Biological specificity, genetic causation, and mathematical modelling in the history of modern biology

Abstract: The concepts of biological specificity (of species, macromolecules, genes etc.) and genetic causality (in particular regarding heredity and development) played an important role in rendering biology a modern experimental science in the nineteenth century. Neglecting these concepts often...

Department of Mathematics
UC San Diego

Title: Correlations and adaptation in enzymatic networks

Abstract: The contrast between stochasticity of biochemical networks and regularity of cellular behavior suggests that biological networks generate robust behavior from noisy constituents. Identifying the mechanisms that confer this ability on biological networks is essential to understanding cells. Here we use stochastic queueing models to investigate one potential mechanism. In living cells, enzymes perform the critical function of...

Kavli Institute of NanoScience and Department of BioNanoScience
Delft University of Technology, Delft, The Netherlands

Title: Fast and accurate target recognition by small RNAs

Bioengineering Department
University of California, San Diego

Title: Investigating the effect of matrix density on the kinematics and mechanics of neutrophil migration in three-dimensional extracellular matrices

Title: Models for the initiation of T cell activation

Abstract: This talk is concerned with mathematical models describing events during the first few minutes after the encounter of a naive mature T cell with its antigen. I will describe results obtained with Eduardo Sontag showing that some of these models exhibit behaviour which had not previously been noticed such as multiple steady states and damped oscillations. In addition I will discuss features of the response function which are predicted by this type of...

Department of Electrical Engineering
Indian Institute of Technology Bombay

Department of Electrical Engineering
Indian Institute of Technology Bombay

Title: Imagining how a cell thinks: The design of reaction network schemes that do machine learning

Abstract: A living cell responds in sophisticated ways to its environment. Such behavior is all the more remarkable when one considers that a cell is a bag of molecules. A detailed algorithmic explanation is required for how a network of chemical reactions...

Title: Couples Oscillations in Biology

Abstract: The control of proteins by a transcription factor with periodically varying concentration exhibits intriguing dynamical behavior. If the concentration of another element, for instance a ligand responsible for the activation of the transcription factor, is oscillating as well, the system of coupled oscillators can create regions of bistable oscillation states. We investigate how transitions between different entrained states caused by intrinsic noise affect the expression of downstream...

Bio: Mary Teruel, Assistant Professor of Chemical and Systems Biology and, by courtesy, of Bioengineering
Biographical Sketch: Mary’s NIH Biosketch...

Title: Human Thought and the Human Future:  A Structural Biologist Offers New Approaches for Solving World Problems ​​​​

Bio: Carl Pabo spent several decades doing research on the structure and design of DNA-binding proteins, making some fundamental contributions to the field.  In 2001, he decided to leave his positions as a tenured professor at MIT and an investigator at the Howard Hughes Medical Institute to look at some even-more-critical questions about the power and limits of human thought....

Title: When good isoforms go bad: Mapping mutation/modification cross talk on KRAS4b in colorectal cancer

Clare Waterman
NIH Distinguished Investigator
Laboratory of Cell and Tissue Morphodynamics

Title: "Active ordering of integrin cell surface receptors by the actin cytoskeleton:
The fundamental basis of directional tension sensing"

... Read more about Seminar: Clare Waterman (POSTPONED)