Associate Professor of Systems Biology
Higgins Lab website
Center for Systems Biology
Massachusetts General Hospital
Simches Research Building
185 Cambridge Street, Boston, MA 02114
Mathematical descriptions of human pathophysiology
Pathophysiology may be described at the molecular, cellular, tissue, and organismal levels and may show clinically significant variation over time scales ranging from seconds to years. My research combines clinical and pathophysiologic insight with dynamical systems theory to pursue two goals: (1) advance fundamental understanding of the dynamics of human pathophysiology, and (2) improve patient diagnosis, monitoring, and treatment.
About Dr. Higgins: I received an AB in Biology from Princeton University and then worked as a computer software engineer at MathWorks, Vermeer Technologies, and Microsoft. He received an MD from the Harvard-MIT Division of Health Sciences and Technology and an SM from MIT. He has done doctoral research with David Altshuler at the Whitehead/MIT Center for Genome Research and post-doctoral research with L. Mahadevan in Applied Mathematics at Harvard University. He completed a Residency in Clinical Pathology at Brigham and Women's Hospital and is a board-certified clinical pathologist in the Department of Pathology at Massachusetts General Hospital. He is the recipient of a 2012 NIH Director’s New Innovator Award.