• We use the tools of mathematics and computation

    Biology is too complicated for the unaided human brain!

  • Location, Location, Location

    We're located in the heart of the Longwood Medical Area, one of the greatest concentrations of biomedical science in the world.

  • Measure twice. Model once.

    Quantitative measurements are essential to build and test worthwhile models.

  • retreat photo hands up

    Systems Biology Retreat in Beautiful Maine!

    Our 2018 department retreat was held at Sebasco Harbor in Maine.

Welcome to the Department of Systems Biology

Systems biology is the study of systems of biological components, which may be molecules, cells, organisms or entire species. Living systems are dynamic and complex, and their behavior may be hard to predict from the properties of individual parts. To study them, we use quantitative measurements of the behavior of groups of interacting components, systematic measurement technologies such as genomics, bioinformatics and proteomics, and mathematical and computational models to describe and predict dynamical behavior. Systems problems are emerging as central to all areas of biology and medicine.


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Upcoming Events

2019 Jan 28

Postdoc Candidate Seminar: Victoria Deneke (Duke University)

11:00am to 12:00pm


ARM 506

Abstract: Early development in most metazoans is characterized by remarkably fast and coordinated cell cycles. Nonetheless, it is unclear how cell cycle synchronization is achieved and maintained across a large developing embryo. We found that cell cycle synchronization in Drosophila arises through the self-organized positioning of nuclei, which is regulated by the spatiotemporal dynamics of the cell cycle, cortical contractions, and cytoplasmic streaming. First, local Cdk1 downregulation at mitotic exit initiates the...

Read more about Postdoc Candidate Seminar: Victoria Deneke (Duke University)
2019 Feb 15

Theory Lunch: Paul Turner

12:00pm to 2:00pm


WAB 563

Department of Ecology and Evolutionary Biology
Yale University

Title: Virus evolvability and the consequences for virotherapy

2019 Feb 19

Stem Cells and the Self Engineering of Animal Embryos- Part 1

2:00pm to 3:00pm


Warren Alpert Building 563
Part one of a four-part lecture series by Alfonso Martinez Arias, Professor of Developmental Mechanick, University of Cambridge. This week's lecture will discuss "the physics and engineering of Developmental Biology."