Special as a Snowflake (Mootha lab)

Special as a Snowflake (Mootha lab)

May 5, 2016

Researchers have determined the structure of part of the tiny passageways that allow calcium ions to enter mitochondria and kick off cellular energy production.

The findings, reported May 2 in Nature, promise to help researchers better understand how the channel, known as the mitochondrial calcium uniporter, works so speedily and precisely and what happens when it breaks—a question of growing interest since mutations in the uniporter have recently been linked to… Read more about Special as a Snowflake (Mootha lab)

 Debbie Marks wins Overton Prize

Debbie Marks wins Overton Prize

April 21, 2016

It’s very exciting to announce that our very own Debbie Marks has won the Overton Prize from the International Society for Computational Biology (ICSB).  The Overton Prize recognizes early to mid-career scientists who are emerging leaders in computational biology and bioinformatics, and is offered in memory of G. Christian Overton, a leading bioinformatics researcher and a founding member of the ISCB Board of Directors.  Previous winners include many of our friends, including… Read more about Debbie Marks wins Overton Prize

MDX Phases

Timing is everything

March 11, 2016

Knocking down MDMX blocks a negative feedback loop on p53 levels, leading to a pulse followed by low-level oscillations.  DNA damage has radically different effects in the two phases.  

Chen SH, Forrester W & Lahav G. (2016). Schedule-dependent interaction between anticancer treatments.
Science. 351(6278), 1204-8 PMID:… Read more about Timing is everything

Time Sensitive

March 1, 2016

There may be an ideal waiting period for delivering multiple cancer drugs. 
read more (HarvardMedicine Magazine)
re: Galit Lahav